What is the Mitochondrial Donation Pilot Program?
The Mitochondrial Donation Pilot Program is a grant opportunity to determine the safety, efficacy and feasibility of implementing mitochondrial donation reproductive technology following the passing of Maeve’s Law.
In April 2022 the Mitochondrial Donation Law Reform (Maeve’s Law) Act 2022 commenced. The design and conduct of the project must be consistent with the requirements of the Act.
Consistent with the Medical Research Future Fund Act 2015 and the Act, the objective of this grant opportunity is to provide a grant of financial assistance to support one Australian medical research and medical innovation project that conducts a pilot program, including a clinical trial, for the purposes of building the evidence base to determine the safety, efficacy and feasibility of implementing mitochondrial donation reproductive technology in clinical practice settings.
In line with the Act, mitochondrial donation techniques will initially be legalised for certain research and training purposes, and for the purposes of a mitochondrial donation clinical trial to provide a pathway for impacted families to access the technology.
The objective of the Medical Research Future Fund (MRFF) – 2022 Mitochondrial Donation Pilot Program Grant Opportunity is to provide a grant of financial assistance to support one Australian medical research and medical innovation project that conducts a pilot program, including a clinical trial, for the purposes of building the evidence base to determine the safety, efficacy and feasibility of implementing mitochondrial donation reproductive technology in clinical practice settings.
The intended outcome of the research is to improve the health and wellbeing of Australians by:
- assisting women whose mitochondria would predispose their potential children to mitochondrial disease to have a biological child who does not inherit that predisposition
- building a body of knowledge through research and ongoing monitoring of trial participants (including children born as a result of mitochondrial donation) to support future government policy decisions regarding broader implementation of mitochondrial donation reproductive technology in clinical practice in Australia.
This grant opportunity is being administered by NHMRC on behalf of the Australian Government Department of Health.
The Australian Government has announced a total of $613.0 million from 2022-23 to 2031-32 for the Emerging Priorities and Consumer Driven Research Initiative. For this grant opportunity, up to $15 million of funding is available over 4 years from 2022-23 to 2025-26 for a single grant to support the Mitochondrial Donation Pilot Program.
To be eligible, activities in your Grant Proposal must clearly demonstrate their criticality in meeting the objectives of the 2022 Mitochondrial Donation Pilot Program Grant Opportunity under Section 1.3 of the guidelines. You can only spend grant funds to pursue the research activities described in your Grant Proposal. You can use the grant to pay costs that arise directly from these activities. The following categories must be used in your proposed budget:
- Equipment – You can request funding to pay for equipment costing over $10,000 that is essential to the research. You must clearly outline the total value of all items of equipment for each year. The Eligible Organisation must be prepared to meet all service and repair costs in relation to equipment funded.
- Personnel (Personnel Support Packages) – Salary contributions for research staff (CIs and Professional Research Persons) are provided as Personnel Support Packages (PSPs). The level of PSP requested in an application must match the roles and responsibilities of the position. Applicants must fully justify all requests for PSPs.
- Other Direct Research Costs (DRCs) – These are costs that are integral to achieving the approved research objectives of a grant where the recipient is selected on merit. DRCs may include personnel costs related to contract staff and limited external persons. The basis for the costing must be included.
Applications will only be accepted from MRFF Eligible Organisations. A list of MRFF Eligible Organisations is available from the GrantConnect GO Documents and from the Approved MRFF Eligible Organisations list on the NHMRC website.
Applications must satisfy all the requirements set out in the Medical Research Future Fund (MRFF) – EPCDR Initiative – 2022 Mitochondrial Donation Pilot Program Grant Opportunity.
Applications close 14 September 2022.